Learn More About Plantar Fibromatosis and
How Transdermal Verapamil 15% Gel Can Help

Causes of Plantar Fibromatosis

An exact cause of plantar fibromatosis is unknown; however, there are some potential causes that most doctors agree may play a role in the condition.


Trauma to the plantar fascia is thought to be a primary cause of plantar fibromatosis. The trauma may be from a puncture through the bottom of the foot or from repetitive impact from activities such as running or climbing. It is also thought that thickening and tightening of the plantar fascia caused by plantar fasciitis may lead to tears in the tissue, causing plantar fibromas to occur.


Did You Know?: Up to 50% of patients with plantar fibromatosis will have Dupuytren's disease.*

Many patients may be genetically predisposed to fibrotic tissue disorders such as plantar fibromatosis. People of northern European descent appear to have a higher incidence of fibrotic diseases, while they rarely affect Asians. People with plantar fibromatosis may also have a parent or a close relative with the condition. The condition is also associated with Peyronie's disease and Dupuytren's disease. About 5% of patients with Dupuytren's disease also have plantar fibromatosis, and 3% of patients with Dupuytren's disease will have Peyronie's disease.

Medications/ Vitamins/ Supplements

Medications often used for treating high blood pressure that belong to the drug class known as beta adrenergic blocking agents (beta-blockers) have been reported to cause fibrotic tissue disorders. Anti-seizure medications such as phenytoin and certain supplements such as glucosamine/chondroitin and large doses of supplemental vitamin C may also promote the production of excess collagen.

Other Conditions

A higher rate of plantar fibromatosis has been found among patients with conditions such as chronic liver disease, diabetes, and seizure disorders**. While these conditions may not be a direct cause of the condition, it may indicate the impact these conditions or medications used to treat them have on wound healing. Long-term alcohol abuse has also been associated with the condition.

*Lee TH, Wapner KL, Hecht PJ. Current concepts review: plantar fibromatosis. J Bone Joint Surg (Br) 1993;75:1080–4.
**Plantar Fibromatosis. 26 Jan. 2007. EMedicine. 12 Jun. 2007. http://www.emedicine.com/derm/topic874.htm