Doctors have tried many different treatments for Peyronie's disease since it was first described in 1678. The most common treatments can be divided into two basic categories, invasive and non-invasive.
Invasive treatments include:
- Injections of verapamil, interferon, or purified clostridial collagenase into the plaque
- Various stretching devices
- Surgery- usually performed as a last resort due to potential unfavorable outcomes such as impotence and loss of penile length. Penile prosthesis is an option if the patient has severe erectile dysfunction.
Non-invasive options include:
- Transdermal Verapamil 15% Gel
- Iontophoresis of different drugs
- ESWT- Extracorporeal Shock Wave Therapy
- Oral Medications such as vitamin E, colchicine, paraaminobenzoate (Potaba®), tamoxifen, and acetyl-L carnitine
Most doctors agree that a conservative approach to treating Peyronie's disease is preferred. As a result, the least invasive options are typically tried first before moving to invasive procedures or surgery in patients suffering from the most significant cases of Peyronie's disease.