Advantages of Transdermal Verapamil 15% Gel
Safe & Non -invasive:
Minimal side effects and no risk of additional damage to healthy surrounding tissue, which is a risk normally characteristic of invasive treatments.
Localized:
Daily localized application enables necessary drug concentration levels to be continually maintained in the affected tissue with little systemic absorption.
Overall Anti-fibrotic Effect:
Application to the entire palmar fascia allows both palpable and non-palpable fibrotic tissue to be treated, aiding in preventing reoccurrence and improving overall tissue characteristics.
Invasive treatment methods pose certain risks. Due to the density of the fibrotic tissue, injection therapy is unable to effectively dispense enough medication to the entire primary nodule or cord in one injection. Therefore, multiple injections must be made which may cause additional trauma to the surrounding tissue and worsen the condition. Additionally, since injection therapy only pinpoints the palpable nodule or cord, any non-palpable fibrosis in the fascia is left untreated, resulting in a less effective treatment.
Surgery poses risk of additional trauma to healthy fascia and is only able to remove the primary nodule or cord, not underlying fibrosis. In addition to the risks typically associated with surgery such as infection, surgery to correct Dupuytren's disease can have downfalls such as nerve damage, stiffness in the fingers, and a high recurrence rate. Long-term postoperative recurrence has been reported as high as 63%*.
Stretching devices and/or splinting only temporarily help symptoms and do not eliminate the fibrotic tissue causing the condition.